Sildenafil and Nitrates: Why This Combination Is Dangerous
Sildenafil and nitrates together can cause a life-threatening drop in blood pressure. Here's the mechanism, the timings, and what to do if you need both.


The original branded tadalafil 10mg, from £4.17 a tablet. Lasts up to 36 hours, with no subscription.
Every strength and pack size at our standard price, next to other UK online pharmacies. No subscription, and the price doesn't go up after your first order.
Strength
| Provider | 4 tablets | 8 tablets | 12 tablets |
|---|---|---|---|
| £19.99£5.00 a tablet | £34.99£4.37 a tablet | £49.99£4.17 a tablet | |
| £20.99£5.25 a tablet | £35.99£4.50 a tablet | – | |
| £20.99£5.25 a tablet | £35.99£4.50 a tablet | £52.00£4.33 a tablet | |
| £22.99£5.75 a tablet | £39.99£5.00 a tablet | £54.72£4.56 a tablet | |
| – | £85.00£10.63 a tablet | – |
Standard prices checked 10 October 2026. Excludes first-order discounts. A dash means the pack is not sold.
Arousal triggers cGMP, a molecule that boosts blood flow to the penis and helps you get an erection.
In people with ED, an enzyme called PDE5 breaks down cGMP too quickly, reducing blood flow and causing the erection to fade.
ED treatments block PDE5, helping more blood reach the penis. This leads to firmer, longer-lasting erections.
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Start consultationExpert advice from our pharmacist team
Sildenafil and nitrates together can cause a life-threatening drop in blood pressure. Here's the mechanism, the timings, and what to do if you need both.
Beta blockers can cause ED, but the risk varies significantly by drug. Bisoprolol carries the highest risk. Here's what the evidence shows and your options.
Fatigue, low libido and mood changes in your 40s or 50s? Here is what 'male menopause' actually means, how it is diagnosed in the UK, and what can help.
There's no age when erections simply switch off. Here's what actually changes decade by decade, why it happens, and what you can do about it.
Maca root is popular with men seeking a natural libido boost. Here's what the clinical evidence actually shows, including dose, timing, and safety.
Sperm replenishment takes around 64 days normally, but months longer after TRT. A pharmacist explains the timeline, what affects recovery, and when to act.
Medically reviewed by

Superintendent PharmacistGPhC: 2220517
This page has been reviewed by our clinical team to ensure it is clear, accurate, and up to date.
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